The cathedral is an impressive complex structure located in the main square of Amalfi. It has ancient origins, and has been renovated a few times through the centuries. The original structure dates back to the ninth century, but the church was completely rebuilt in 1203 in Arabo-Normanno styles. The cathedral's front is rich with many golden mosaics, and it was rebuilt in 1861.

The central mosaic is by Domenico Morelli. The bronze doors of the Duomo were casted in Costantinopoli in 1066, at the time, the town of Amalfi was a powerful sea-republic.

The doors are decorated with figures of Christ, Mother Mary, and the Saints Andrea e Pietro.

The crypt, built in 1253, is really worth a visit.